However, a staining intensity analysis demonstrated that oropharyngeal and oral cavity cancer tissues infected with transcriptionally active HPV (p16+) showed a decrease in MIF expression compared to oropharyngeal and oral cavity cancer tissues not infected by HPV (n = 21 and n = 65 respectively) (Figure 1, p = 0.001 and p = 0.004 respectively, Kruskal-Wallis test). Here, MIF is linked to oral cavity cancer.