MIF and neoplasm: In addition, we have observed, for the first time, that MIF expression decreased in the tumor cells of HNSCC patients with HPV infection, and that MIF secretion was increased in HPV-positive cell lines, an observation that we confirmed by demonstrating resistance to an inhibitor of MIF (4-IPP) in human cell lines that were infected with HPV, as well as in murine cell lines expressing the E6 and/or E7 oncoproteins.