Intriguingly, we did observe that GEF-H1 showed partial co-localisation with the MNV RC (Figure 1) and a substantial association between MNV NS3 and GEF-H1 (Figure 3), suggesting that during infection, the NS3 protein may modulate the functional capacity of GEF-H1 to sense and respond to MNV infection. This evidence concerns the gene ARHGEF2 and infection.