Recent research has shown that KRT8/KRT18 protein levels are markedly increased in TNF-related apoptosis inducing ligand (TRAIL)-resistant cells compared to TRAIL-sensitive breast cancer cells, and they may limit TRAIL-induced apoptosis signaling via negatively regulating death receptors’ (DR5) protein stability and surface expression [46]. This evidence concerns the gene TNFSF10 and breast carcinoma.