GLS and non-small cell lung carcinoma: As an example, dual inhibition with the GLS-inhibitor bis-2-(5-phenylacetamido-1,3,4-thiadizol-2-yl)ethyl sulfide (BPTES) and its pyrimidine analogue elicited cell death synergistically through cell cycle arrest, and resulted in a remarkable anticancer effect in a preclinical NSCLC model [42].