CTLA4 and Hashimoto thyroiditis: The CTLA-4 gene is located on chromosome 2q33 and contains two further functional polymorphisms, the CTLA-4 rs733618 and CTLA-4 rs3087243, which are associated with enhanced T cell reactions and higher susceptibility to autoimmune diseases, such as myasthenia gravis [23], systemic lupus erythematosus [24,25], Hashimoto thyroiditis [26], latent autoimmune diabetes [27], multiple sclerosis [28] and acute liver transplant rejection [29].