IL6 and colitis: For example, these FAHFAs were reported to suppress the number of macrophages positive for tumor necrosis factor (TFNα) and interleukin 6 (IL-6); prevented the activation of the immunosuppressive enzyme indole amine 2,3-dioxygen in human blood; and decreased T-cell activation and colitis associated inflammation in a mouse model of ulcerative colitis [9,25].