LDOC1 and lung carcinoma: Considering the effect of cigarette smoke-induced epigenetic aberrations on the development and progression of lung cancer, confirming the importance of the methylation-dependent silencing of LDOC1 in this malignancy by performing in vivo analysis that entails the induction of hypermethylation on the LDOC1 promoter through CRISPR/Cas9–mediated knockin of DNMTs is necessary.