Many clinical investigations suggested that low adiponectin concentrations are associated with an increased risk of breast cancer (OR (Odds Ratio) = 3.63 [153] and OR = 0.84 [154]) and such an interaction has also been reported with menopausal status (RR = 0.73 among postmenopausal women and 1.30 for premenopausal women [155] and SRR (Standardized Relative Risk) = 0.80 and =0.72 in post and premenopausal patients, respectively [156]). This evidence concerns the gene ADIPOQ and breast carcinoma.