ERBB2 and neoplasm: More recently, increased BMI was also positively correlated with a higher risk of less aggressive tumor subtypes, as defined by clinically used biomarkers (ER+, PR+, HER2 (Human epidermal growth factor receptor 2)−, Ki67low, Bcl-2 (B-cell lymphoma 2)+, and p53−), among postmenopausal women who were non-users of estrogen–progestin therapy [50].