Here, we have shown that ENA78/CXCL5 and ICAM-1 were significantly decreased in TNF-α-stimulated ADAM15 siRNA-transfected HUVEC-conditioned medium compared with TNF-α-stimulated control medium, suggesting that ADAM15 plays an important role in angiogenesis in RA through regulating the expression of ENA-78/CXCL5 and ICAM-1. The gene discussed is TNF; the disease is rheumatoid arthritis.