Hence, we demonstrated ADAM15 siRNA-treated HUVECs had decreased EC tube formation in Matrigel in response to RA SFs compared with non-treated HUVECs (number of EC tubes 4 ± 1 and 1 ± 0, respectively, p < 0.05, Figure 3C–E). The gene discussed is ADAM15; the disease is rheumatoid arthritis.