In NUT-midline carcinoma, a translocation that fuses the BRD3 or BRD4 protein to the NUT transcriptional regulator creates an oncoprotein that, through binding to acetylated histones, is thought to promote transcription of proliferation genes (e.g., MYC proto-oncogene) [33]. This evidence concerns the gene BRD4 and nut midline carcinoma.