Well-characterized examples of reader domains include: Bromodomains (BRDs) typically binding acetyl-lysine; chromatin organization modifier (chromodomains, CRDs), malignant brain tumor (MBT), proline–tryptophan–tryptophan–proline motif (PWWP) as well as Tudor domains generally associated with methyl-lysine, and plant homeodomain (PHD) associated to multiple substrates [17]. The gene discussed is PDC; the disease is brain cancer.