PHF19 and leukemia: Further, synthetic RNA interference-based approaches have been extensively used in preclinical settings to dissect molecular consequences derived from readers’ inhibition, such as PHF19 in melanoma [66], PHF20L1 (Tudor domain-containing protein) in breast cancer [67], and WDR5 in leukemia and pancreatic cancer [68,69], all inhibiting tumor progression in vitro and/or in mouse models.