In order to test this hypothesis, we carried out a quantitative methylation analysis of CpG islands at promoter regions of 12 known cancer genes (BRCA1, BRCA2, ATM, CDH1, FANCM, STK11, NBN, PALB2, PTEN, RAD51C, RECQL and TP53), on a large cohort of 154 unrelated women affected with eoBC and selected for negative FH. This evidence concerns the gene RAD51C and cancer.