Given that overexpression of FGFR4 significantly correlates with EpCAM, a marker of hepatic cancer stem cells, within the fatty liver-steatosis-cirrhosis-HCC sequence [66], FGFR4 may have the ability to regulate cancer stem cells and lead to chemoresistance in HCC or other cancers. The gene discussed is FGFR4; the disease is hepatocellular carcinoma.