The activity of cMDH increased in the ALS I and ALS I SWIM groups (2.333 ± 0.11 and 2.077 ± 0.11 μmol/min/mg of protein, respectively) vs. the ALS 0 group (1.166 ± 0.08 μmol/min/mg of protein) (p = 0.0001) and corresponding WT group of mice (p = 0.0001). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.