TNC, which is composed of 6 monomers linked at their N-termini with disulfide bonds, is a large hexameric extracellular matrix protein that involved in tumor growth, migration, metastasis, tumorigenesis and immunosuppression.[14,20,26] TNC is transiently expressed in many developing organs or under tissue regeneration, but it may maintain sustained TNC activity in tumors. This evidence concerns the gene TNC and neoplasm.