TNC and cancer: Yang et al found that breast ductal carcinoma patients with positive expression of TNC has a shortened overall survival compared to the negative group,[19] while diametrically opposing conclusions were drawn by Shoji and colleagues.[28] This phenomenon may attribute to different sources of TNC because a functional difference in TNC may exist between the cancer cells and stromal cells.[20] In this study, we found that positive features of TNC expression were mainly localized in the cytoplasm of tumor cells and extracellular matrix.