Conditional deletion of Itga11 from LepR+ cells phenocopied the effect of Osteolectin deficiency (Yue et al., 2016): in both cases the mice were grossly normal but exhibited accelerated bone loss during adulthood, particularly in trabecular bone (Figure 5). The gene discussed is LEPR; the disease is hyperinsulinemic hypoglycemia, familial, 4.