Its main function being the regulation of intercellular adhesion and is also involved in the expression of genes.37 The level of expression of β‐catenin also directly impacts the activation of the Wnt signal pathway.38 When the degradation of β‐catenin becomes an obstacle, too much β‐catenin accumulates in the endonuclear membrane leading to cancer via an abnormal activation of the Wnt signal pathway.39 In 2012, Tanya et al reported that the function of Trop2 requires the presence of β‐catenin in nucleus. Here, TACSTD2 is linked to cancer.