We found that AUC value (0.684 (0.586‐0.782)) of this model was much higher than any single AUC value from the three clinical factors (0.597 (0.499‐0.695) for age, 0.592 (0.494‐0.690) for CNA, 0.619 (0.521‐0.717) for neoplasm status; Figure 4A) and the three mRNAs (0.532 (0.434‐0.630) for TBX21, 0.563 (0.465‐0.661) for TGIF2, 0.536 (0.438‐0.634) for CYCS; Figure 4B), which was validated in the testing set (n = 703) integrated by another 4 independent datasets (Figure 4C), although not all results reached statistically significant. This evidence concerns the gene TGIF2 and neoplasm.