In recent years, IL‐27 gene polymorphisms shown in quite a few studies were associated with infectious disease susceptibility.11, 12, 13 Additionally, IL‐27 plasma level becomes lower in HIV‐infected patients, which was proved by Zheng et al.14 Moreover, polymorphisms of some genes such as BST2,15 BSSL,16 APOBEC3H17 have been proposed to be related to the progression of HIV infection. The gene discussed is IL27; the disease is infectious disease.