Our data, it is true, showed no direct association between IL‐27 polymorphism and HIV viral road, but we suspect that IL‐27 rs40837 polymorphism might influence the susceptibility to HIV infection and disease progression probably by regulating the level of serum IL‐27 or the quantity of CD4+T. However, the specific mechanism is not yet clear and more researches, especially for different countries, different races are warranted to verify our view as a result of the genetic heterogeneity in different ethnic groups. This evidence concerns the gene IL27 and HIV infectious disease.