Host genetic variation is an important determinant of HIV infection and disease progression.18 Moroever, cytokines are involved early in the pathogenesis of HIV infection and disease progression as a essential component of immunological dysregulation and immunodeficiency and as determinants controlling virus replication.9 IL‐27, a cytokine mainly produced by dendritic cells, monocytes, and phagocytic cells, has been shown to interfere HIV‐1 virus replication(against HIV‐1 infection)with controversial findings. This evidence concerns the gene IL27 and Immunodeficiency.