Interleukin‐27 (IL‐27) composed of Epstein‐Barr virus‐induced gene (BBI3) and p28 protein, a member of IL‐12 family,6 is a heterodimeric immunoregulatory cytokine involved in early Th1 initiation7 and can affect T‐cell proliferation and cytotoxic activity.8 The influences of IL‐27 on HIV infection and replication have been discussed, an experiment using HIV infected mice as a model proved that IL‐27 could increase dendritic cell functions, in addition, a more direct function of IL‐27 is performed in an in vitro test, which is the inhibition of R5 and X4 HIV replication.9 Here, IL27 is linked to HIV infectious disease.