Encouragingly, the response rates in non-melanoma skin cancers follow a similar trend, with avelamub (anti-PD-L1 antibody) now approved as first-line therapy for metastatic MCC, and cemiplimab (anti-PD-1 antibody) granted FDA priority review in 2018 for SCC, with clinical trials are underway for BCC (NCT03132636, NCT02690948). Here, CD274 is linked to skin basal cell carcinoma.