CD274 and cancer: Here, we offer a brief overview of the current and emerging standard-of-care drugs used in cancer immunotherapy for metastatic skin cancers, and provide updates on immune-related biomarker advancements pertaining to MM, BCC, SCC, and mMCC, including TMB, PD-L1, novel immune activation/exhaustion markers, as well as relevant cytokines/chemokines, highlighting research that may be invaluable for the diagnostic, prognostic and predictive information helpful in establishing better clinical outcome.