Only three panels recently published are specifically designed for MSI detection in cancer, namely the MSIplus panel which evaluates mutations in 3 oncogenes (KRAS, BRAF, and NRAS) and 17 microsatellites (49), the ColonCore Panel which allows the simultaneous detection of MSI and mutations in 36 CRC-related genes principally proposed for CRC (48), and a pan-cancer panel of 111 microsatellite loci highly informative in cancer (46). This evidence concerns the gene NRAS and cancer.