To understand schistosomiasis-associated carcinogenesis, Botelho and colleagues demonstrated that inactivation of p27 and upregulated expression of B-cL2 contributed to cancer hallmarks (mainly stimulated cell proliferation and inhibited apoptosis) in Chinese hamster ovary (CHO) cells challenged with lysates of S. haematobium eggs and adult parasites. The gene discussed is BCL2; the disease is cancer.