In the current study, we tested this hypothesis by comparing the frequencies of genetic variants of a DCDC2 expression regulator called READ1 (regulatory element associated with dyslexia (1)32 in children with unexpected poor comprehension, expected average comprehension, and unexpected good comprehension, from the US-Canada collaborative Genes, Reading and Dyslexia (GRaD) Study. The gene discussed is DCDC2; the disease is dyslexia.