ANPEP and early-onset autosomal dominant Alzheimer disease: We highlight 2 examples of CpGs, which are implicated by all 4 analyses: cg23161492 in ANPEP (a gene previously identified in the GWAS of Type 2 diabetes69 and implicated in major depressive disorder by pathway analysis70) and cg04907244 in SNORD93, a snoRNA that was previously reported as a potential early diagnostic marker of Alzheimer’s disease because it was found to be differentially expressed in juvenile cortices of a mouse model for Alzheimer’s disease.71 Both CpGs were also associated with gene expression levels in cis in blood (Supplemental Table 7).