TRPV1 and TRPA1 are well-described targets for various pungent compounds such as capsaicin (TRPV1) and mustard oil (TRPA1 and TRPV1)54 and could render rosacea stimuli such as heat (TRPV1)55, possibly cold temperatures (TRPA1)56, UVB irradiation (TRPV4)57, and toxins and cosmetics ingredients (for example, TRPA1)58 into clinical rosacea manifestations. This evidence concerns the gene TRPV1 and rosacea.