This study showed that the highest response rate was observed in patients with MM treated with anti-PD-1, with nearly 20% (95% CI: 11.6%-30.8%) of responses relative to 3.9% (95% CI: 0.8%-11.1%) with anti-CTLA-4 mAb and 14.1% (95% CI: 7.3%-23.8%) with chemotherapy. This evidence concerns the gene PDCD1 and Miyoshi myopathy.