TNF and Hepatic fibrosis: In conclusion, the protective effect of Proliverenol in CCl4-induced liver fibrosis in rats appears to stem from its antioxidant capacities as indicated by protection against increased lipid peroxidation and decreased ratio GSH/GSSG and its ability to suppress proinflammatory cytokines TNF-α and to inhibit HSC activation by reducing profibrogenic cytokines TGF-β1.