The development of liver fibrosis is a dynamic process characterized by deposition of collagen and other cellular matrix proteins, following activation of HSC into myofibroblast-like cells which resulted in the secretion of several profibrogenic cytokines such as TGF-β, endothelin-1, and platelet-derived growth factor [21, 22]. The gene discussed is EDN1; the disease is Hepatic fibrosis.