However, the prognostic value of ApoE expression for CRC remains unclear, and to the best of our knowledge, although some previous research has been implicated that APOE might influence CRC development through three potential path ways: cholesterol and bile metabolism, triglyceride and insulin regulation, and the prolonged inflammation (Slattery et al., 2005; Mrkonjic et al., 2009; Kato et al., 2010), there has not been a prior study of functional expression and prognostic significance for CRC. This evidence concerns the gene APOE and colorectal carcinoma.