The multivariate analysis demonstrated that ApoE expression in PC was an independent prognosticator for OS (HR 1.559, [95% CI 1.096–2.216]) and PFS (HR 1.541, [95% CI 1.129–2.104]) in patients with synchronous liver metastasis CRC (Tables 4, 5 and Supplementary Tables S6, S7). The gene discussed is APOE; the disease is pachyonychia congenita.