IFN-γ supports anti-tumor activities in multiple ways by upregulating major histocompatibility complex-I (MHC-I) in tumor cells, inhibiting the process of angiogenesis and tumor cell proliferation, and at the same time augmenting cytotoxic effector cell functions of CTLs, NK cells, macrophages, and CD4+ T cells polarization (69). Here, CD4 is linked to neoplasm.