A study using over-expression system revealed that TRAIL+ T cells induced less GVHD but augmented GVT effect (137), while another study reported that the level of soluble TRAIL in peripheral blood after allo-HCT was corelated with better prognosis with less GVHD (138), suggesting that TRAIL may be a feasible target for GVHD and GVT management. This evidence concerns the gene TNFSF10 and graft versus host disease.