Although the CD8+ T cell responses toward the HLA-A2.1-restricted WT1126−134 epitope “RMFPNAPYL” (herein called WT1A, Table 4) have been identified in various HLA-A2+ cancer patients, research and clinical trials using WT1A peptide vaccination strategies have been disappointing (57, 59, 60). This evidence concerns the gene CD8A and cancer.