Nevertheless, given that Karikoski et al. showed significantly decreased numbers of Tregs were present in their murine tumor models when stabilin-1−/− mice were compared to WT controls (231), it can be speculated that stabilin-1's role in the recruitment of Tregs across HSEC will be potentially important in the context of hepatocellular carcinoma (HCC). The gene discussed is STAB1; the disease is hepatocellular carcinoma.