For example, Thijs et al. (12) analyzed 147 serum analytes (representing biomarkers for apoptosis, chemokines, growth factors, complement activation, epithelial cytokines, galectins, glucose regulation, immunomodulatory cytokines, inflammatory biomarkers, innate immunity biomarkers, leukocyte migration biomarkers, neutrophil/granulocyte biomarkers, proteases, and protease inhibitors, remodeling biomarkers, TH2 cytokines, vascular regulation, viral response and serum total and allergen-specific IgE) obtained from patients with moderate to severe AD (n = 200). The gene discussed is IGHE; the disease is Alzheimer disease.