“Cell Cycle: G1/S Checkpoint Regulation” in particular was predicated to be downregulated upon VEEV-TrD infection (z-score of −2.132), though a few individual genes within the pathway were upregulated, such as the cell cycle progression transcription factor c-MYC and the glucogenesis transcription factor FOXO1 (Figure 4). The gene discussed is FOXO1; the disease is infection.