Based on our findings that sumoylated Flot-1 translocates to the nucleus in mitogenic response, and stabilizes Snail for induction of EMT-related genes in metastatic prostate cancer, we would speculate that palmitoylated Flot-1 localized in the PM microdomains might regulate cadherin stabilization at cell–cell junction, presumably via a dynamic palmitoylation turnover of the PM-targeted Flot-1. This evidence concerns the gene FLOT1 and metastatic prostate carcinoma.