Thus our data indicate that sumoylation of the non-palmitoylable Flot-1 is likely to take place in the ER by ER-localized UBC9, and the sumoylated Flot-1 is translocated to the nucleus to stabilize Snail for the EMT of metastatic prostate cancer in mitogenic response (Fig. 6e). Here, SNAI1 is linked to Familial prostate cancer.