DU145 cells, another prostate cancer cells with high metastatic potential [27], also exhibited the elevated expression of Snail and UBC9 (Supplementary Fig. S1a), and the mitogen-response sumoylation of Flot-1 by SUMO-2/3 (Supplementary Fig. S1a, b). Here, SUMO2 is linked to Familial prostate cancer.