Recently, we have shown that palmitoylation of Flot-1 at Cys-34 in the endoplasmic reticulum (ER) is required for the transport of IGF-1R with the Flot-1 to the plasma membrane (PM), and IGF-1-induced Flot-1 palmitoylation turnover in the PM prolongs IGF-1R signaling activation to promote cancer cell proliferation [3]. Here, IGF1R is linked to cancer.