This could suggest a connection between EPAS1, EGLN1, and Hb production, especially based on what we know about Tibetan and Andean populations whose genetic variation in both genes has been implicated in protecting individuals from erythrocytosis/polycythemia, resulting from living at high-altitude (Peng et al. 2017; Peng et al. 2011; Wu and Kayser 2006). This evidence concerns the gene GSTM1 and polycythemia.