Validating these results, we observed no significant differences in cancer cell proliferation or motility between cells treated with conditioned media from CAF1 (detectable secreted DKK3, as per Fig. 2b) or CAF5 (no detectable secreted DKK3), or in the presence of a blocking antibody against DKK3 (Supplementary Figure 5e). The gene discussed is DKK3; the disease is cancer.