CDC42 promotes the invasion and migration of many human cancers, including CRC32, lung cancer33, breast cancer34, esophageal cancer35,36, gastric cancer37, renal cell cancer38, cervical cancer17, etc. And high CDC42 expression has been reported to correlate with CRC development, CDC42 can be used as a biomarker and therapeutic target of CRC25,39. The gene discussed is CDC42; the disease is colorectal carcinoma.