AMER1 and colorectal carcinoma: MiR-20a/106a inhibits WTX expression, blocks RhoGDIα/CDC42 complex formation, subsequently promotes CDC42GDP dissociation from RhoGDIα and transformation into CDC42GTP, thus activating the downstream pathway which results in F-actin remodeling, increased cell proliferation, polarity, and migration ability, and finally leads to catalyzing CRC progression and liver metastasis (Fig. 7).