Further studies revealed WTX is a target of miR-20a/106a in CRC cells, and miR-20a/106a negatively regulates WTX/RhoGDIα/CDC42-MRCKa-LIMK1/2-Cofilin pathway by preventing WTX expression thus promoting CRC liver metastasis. Here, AMER1 is linked to colorectal carcinoma.