RB1 and colorectal carcinoma: Previous studies have found that miR-20a/106a overexpressed in CRC is correlated with aggressive biological behaviors, including promotion of the cell cycle52, drug resistance53 and RB tumor suppressor gene inhibition54, therefore our study uncovered the function and mechanism of miR-20a/106a in CRC, and as miR-20a/106a drive WTX loss induced CRC cells to gain the migration ability, we can predicate that inhibiting miR-20a/miR-106a might provide an intriguing target for CRC treatment.