The above observation that KDM6B overexpression was sufficient to induce neuroblastoma cell differentiation prompted us to investigate whether KDM6B has a role in the action of RA, which is commonly used for induction of neuroblastoma cell differentiation9,10 and has been used in clinic for treatment of high-risk neuroblastomas11–14. This evidence concerns the gene KDM6B and neuroblastoma.