Osx expression was significantly correlated with lymph node metastasis, whereas there was no statistical significance between Osx expression and patients’ age, tumor size, TNM stage, or histological sub-type (ER, PR, AR, HER2 status), nor was there an association between Osx expression and Ki-67, EGFR, P53, or CK56 expression (Table 1). Here, SP7 is linked to metastatic malignant neoplasm in the lymph nodes.