To further corroborate the notion that a loss of CUL5 may play a role in the progression of ccRCC, we analyzed The Cancer Genome Atlas (TCGA) Kidney Renal Clear Cell Carcinoma (KIRC) cohort, a large patient cohort (n > 400) for which both clinical and genomic data are available (Fig. 5). This evidence concerns the gene CUL5 and nonpapillary renal cell carcinoma.