Moreover K5-CYLDC/S mice show an early diffuse alopecia, progressive with age, which could be the result of both the constitutive activation of the canonical pathway of NF-κB, and the increased expression of its targets, the pro-inflammatory cytokines TNF-α and IL-6, as inflammation is known to be linked to the development of the most common form of alopecia in humans, the androgenetic alopecia [35]. Here, TNF is linked to alopecia.