CYLD and neoplasm: In support of our hypothesis is the fact that although the function of CYLD as a tumor suppressor has been reported for different types of cancer [53]; however, none of the other two models of mutant CYLD transgenic mice (i.e. the CYLDm and CyldE∆9/∆9 mice) develop cancer spontaneously, strongly suggesting that the reason for this may be that they do not age prematurely.