Different evidences support the role of these proteins in skin cancer development and progression, i.e., the activity of NF-κB increases with the skin tumor progression, supporting the pro-tumoral action of NF-κB in the cutaneous SCC [49]; also, NF-κB and JNK activation cause tumor development in familial cylindromatosis patients [1,2]. The gene discussed is MAPK8; the disease is Brooke-Spiegler syndrome.