MAPT and Alzheimer disease: In order to assess the impact of Aβ deposition or the downstream processes of the amyloid cascade (i.e. tau pathology and neurodegeneration), we applied the recently proposed A/T/N classification framework of AD, which proposes 3 binary biomarker groups [27]: (1) aggregated Aβ (A+/A-), (2) aggregated tau (T+/T-) and (3) neurodegeneration (N+/N-).