In support of this finding, levels of CD11c+ DC increased upon (chemo-) immunotherapy (58.2 ± 31.1 cells/HPF vs. vaccine: 107.5 ± 70.1 cells/HPF vs. control: 45.0 ± 16.5 cells/HPF), while numbers of F4/80+ (tumor-associated) macrophages decreased (50.3 ± 46.1 cells/HPF vs. vaccine: 52.7 ± 48.2 cells/HPF vs. control: 68.3 ± 30.2 cells/HPF), indicative for phenotypic (and eventually functional) polarization (Fig. 8). The gene discussed is ITGAX; the disease is neoplasm.