Sirt6-null iPS-like cell has also shown that lower efficiency of hematopoietic progenitor cell generation in vitro further indicates the differentiation defect of this cell line although teratoma tissue with normal hematopoiesis tissues in vivo (Fig. 4e, f), which is consistent with a recent study that Sirt6 is required for the hematopoietic stem cell homeostasis [32]. This evidence concerns the gene SIRT6 and teratoma.