By multivariate survival analysis using Cox proportional hazards regression, Bcl-2 positivity was associated with a longer disease-free interval (HR = 0.57, 95%-CI: 0.34–0.96; p = 0.034) independently of the pathologic tumor size (pT ≥ 20 mm: HR = 1.52, 95%-CI: 1.04–2.21; p = 0.029), and positive nodal stage (pN+ compared to pN0: HR = 2.36, 95%-CI: 1.27–4.41; p = 0.007; Table 3). This evidence concerns the gene BCL2 and neoplasm.