For example, Hwang et al. [9] showed in a series of 7230 primary breast cancer patients, that Bcl-2 positivity was associated with better overall survival (HR, 0.42; 95%-CI, 0.42–0.71; p < 0.001), independently of patient age at diagnosis, the histologic grade, tumor size and nodal stage, hormone receptor and HER2 expression, and lymphovascular invasion. This evidence concerns the gene ERBB2 and breast cancer.