Activated NF-κB translocates from the cytoplasm into the nucleus, and then promotes the expression of its target genes such as monocyte chemoattractant protein (MCP-1) and transforming growth factor-β1 (TGF-β1), which are important pro-inflammatory cytokines in DN progression [2, 11–13]. This evidence concerns the gene CCL2 and liver dysplastic nodule.