As shown in Fig. 3a-b, in the paired cohort, TIM-3 expression in the primary or metastatic tumor was not associated with PFS (HR:0.684, 95% CI 0.392–1.194, P = 0.254), except for OS (HR: 0.4, 95% CI 0.206–0.787, P = 0.006). This evidence concerns the gene HAVCR2 and metastatic neoplasm.