In the gastritis group, the oipA “on” status was positively correlated with the presence of cagA (r = 0.27, P = 0.02) and vacA s1 m1 (r = 0.30, P = 0.01), but negatively correlated with the presence of vacA m2 allele (r = − 0.44, P = 0.001). The gene discussed is S100A8; the disease is gastritis.