The remaining twenty-two patients with suspected VWD were further analysed with respect to their response to Haemate® P. While the reaction to the VWF was heterogeneous in n = 15 patients (Table 1, marked in red, so-called low responders), we found a clear-cut reaction in n = 7 patients (Table 1, marked in green, so-called high responders) to VWF. The gene discussed is VWF; the disease is von Willebrand disease (hereditary or acquired).