GATA6 and pancreatic agenesis: GATA4 is an obvious choice for a genetic modifier, given its expression in the DE, genetic interaction with Gata6 in mice, and the identification of rare GATA4 heterozygous patients with pancreatic agenesis, as well as our finding that GATA4 is bound and regulated by GATA6 in vitro (Figure 3) (D'Amato et al., 2010, Freyer et al., 2015, Morrisey et al., 1996, Shaw-Smith et al., 2014).